According to this prevailing
schema, the decision between lymphoid and myeloid lineages occurs very early. Natural killer
(NK) cells are innate immune effector cells. Their derivation from either lymphoid or myeloid
lineages was debated early in their discovery. Further research showed that NK cells can be
derived from common lymphoid progenitors and hence have been considered separate from
myeloid lineage. However, some studies question this and have shown that progenitors
expressing myeloid antigens can also develop into NK cells. However, alternative views have
been proposed, including the existence of a common myelo-lymphoid progenitor and this
process depending on which cytokines are they exposed.
NK cells are unique, since they have the ability to recognize stressed cells in the absence
of antibodies and MHC, allowing for a much faster immune reaction. So, NK cells, as part of the
innate immune system, play a key role in host defense against viral infections and tumor cells.
The notion that myeloid precursors previously known to give rise to monocyte/macrophage and
Dendritic Cells (DCs) are also capable of NK-cell differentiation puts the recent findings in a new
therapeutic perspective.
Endorphins and enkephalins, small peptides, are produced by the central nervous
system, by the pituitary gland (hypophysis) and by cells in the adrenal medulla, intended to
mean a morphine-like substance originating from the body itself. They have potent painkilling
effects leading to analgesia and behavioral changes, producing states of euphoria. One of the
important effects of these molecules is the activation of NK cells, increasing the vigilance of
these cells against cells altered by infection or neoplasia
Many people that are taking or had taken M8 and M1 related they became better
aware of the side effects of chemotherapy, increased their well-being, decreased pain, etc. In
one of our doctoral thesis it was seen that the homeopathic complex M1 increased the
differentiation of NK cells from Blood Mononuclear Cells, besides also increased their activation
in a significant manner. These two facts strongly suggest a link between endorphins and
activated NK, and this could explain the good results found with this medicine in several
diseases. It would be possible to differentiate and activate in vitro self NK cells and reintroduce
them in the body to increase their own defenses against some viruses or tumors? Without side
effects, using inexpensive homeopathic products…, I am sure that it could be helpful in a nondistant future.
img. : Scanning Electron Microscopy from peripheric human blood where it can be seen erythrocytes
and leukocytes