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Clinical Trials

New Virus Variants And Immunocompromised Individuals


Viruses have been able to reproduce and populate the Earth for billions of years, long before human life. The potential for mutation and adaptation to new biological environments is the key to the evolutionary success of viruses.The mutation process is natural in the biological history of any virus. When entering a cell, a single virus can generate thousands of new copies - its reproduction is extremely fast. To multiply, its genetic material is introduced into the host's cells. During the replication process, the enzymes responsible for the copies can introduce errors in the genome (changes in the "little letters" that make up the genetic code). The higher the transmission rate, the greater the chances of new variants appearing. Most of these changes are harmful, and the viruses that acquired these mutations end up being eliminated. But as they produce thousands of new copies, the variants that are selected, necessarily have some advantage. Many of them are more infectious, bind more strongly in cells and become more transmissible.

Another point, perhaps the main one at that moment, is that some of the variants alter the protein on the virus surface and make antibodies generated by a previous infection or a vaccine more difficult to bind on the surface of this virus, consequently causing a phenomenon called immune escape, extremely dangerous, since it allows reinfection. There are proven cases, but more robust studies are lacking to assert that the new variants are really able to circumvent the immune system and cause a new infection.

One hypothesis about the origins of these variants is through intra-host viral evolution due to prolonged infection in an immunocompromised host. Recent studies have shown that persistent SARS-CoV-2 infections in immunocompromised patients can trigger the accumulation of an unusual high number of mutations with potential relevance at both biological and epidemiological levels. So, it is fundamental that immunocompromised individuals are not contaminated, for their own survival and to avoid this chronically underlying COVID19, facilitating the emergence of new variants. An efficient way to prevent this is to activate this immune system that is depressed by taking ANBUTA PLUS, a product resulting from more than 20 years of research, with no toxicity and no side effects.



PROF. DR. DORLY BUCHI, SWITZERLAND

Natel Neutratec (India) Pvt. Ltd.